Rodzaj przeciwciał

Type of the autoantibodies
Antigen:
Polinucleotides
Histones
Type of the fluorescence
n DNA, ds DNA
ss DNA
homogenous,
homogenous
RNA
Partially nucleolar
H 1- 4
Homogenous ,
U1-n RNP
Sm
Rybonukleoproteins
Nukleases (ENA)
SS-A (RO)
SS-B (LA)
macrogranular, peripherically
homogenous
macrogranular, granular
Autoimmune disease
Systemic lupus erythematosus (SLE)
(SLE)
Drugs induced lupus
Mixed conncetive tissue disease
(MCTD)
Polymyositis/Dermatomyositis
Progressive systemic sclerosis (PSS)
Sjögren syndrome
Reumathoid arthritis (RA)
SLE
Scleroderma
Sjögren syndrome
SLE
RA
MCTD, U1-RNP
RA U1-RNP
SLE Sm+U1-RNP
Sjögren syndrome SS-A+SS-B
SLE SS-A+SS-B
Neonates lupus
SS-A
ANA –
antinuclear antibodies
U3-nRNP/fibrylaryna Granular nucleoli,
RNA – Polimeraza I Ring around the chromosomes
PSS
PM-Scl
Nucleoli
Homogenous nucleoli,
small dots peripherically
Overlap syndrome
PSS
7-2-RNP
4-6-S RNA
Hommogenne jąderka,
Antygeny jąderk
Postępująca twardzina uogólniona
Nucleoli organizer
(NOR)
Dots in nucleoli
Kinetochor proteins
Nuclear and spindle granules
PSS-limited
Closely homogenous
PSS-disseminated
microgranular, 50% of the nuclei
are brighter,
small dots around chromosomes
SLE
Nuclear dots – 5-20 ziarn.
Reticular,
microgranular
Primary biliar cirrhosis
SLE
Dermatomyosistis, polymyosistis
laminar
Autoimmune hepatitis (AIH)
Centromeres
Scl-70
PCNA cycline
Other proteins
Nuclear granules
Ku
Mi-1
Mi-2
Nuclear lamina
Primary billiar cirrhosis
AMA –
antimitochondrial
antibodies
Mitochondrial
Dots in the cytoplasm, mostly in
distant compartments
M2+M4+M8+M9 + NUCLEAR DOTS
Different forms of lupus
APCA –
przeciwciała przeciw
strukturom komórek
okładzinowych żołądka
Tkankowe
LKM –
Tissues
Fluorescencja komórek
okładzinowych błony śluzowej
żołądka
Wrzód żołądka
Nieżyt przewlekły żołądka
Zapalenie tarczycy Hashimoto,
Anemia
Dependent on the cell line used
In hepatocytes- homogenous
cytoplasm,
Small dots in proximal tubulocytes
No fluorescence in distal
tubulocytes
Chronic AIH
Granular cytoplasm
Granulomatosis and vasculitis
(previously Wegener’s
granulomatosis)
Linear perinuclear
Vasculitis
cANCA
Cytoplasmatic
ANCA –
Antibodies agains
granulocytes cytoplasm
pANCA
Perinuclear