Synthesis of Clonazepam

Synthesis of Clonazepam
H
O
N
N
O2N
Cl
Clonazepam
NH2
Cl
O
NH2
HO
NH2
1)
NH2
+
O2N
O
Cl
Cl
+
2)
O
HO
O
Cl
Cl
+
3)
HO
O
Cl
Cl
4)
O
Cl
+
NH2
Cl
O
O
O2N
Cl
AlCl3
Cl
+
5)
O
H
N
NH2
N
O
O2N
O2N
6)
H+
Cl
+
cat.
Cl